Manchester United manager Ole Gunnar Solskjaer said his decision to play Marcus Rashford “backfired” after the striker went off with a back injury.
Rashford, 22, was replaced in the 80th minute after he had been on the pitch for 16 minutes as United beat Wolves 1-0 in their FA Cup third-round replay.
The England international has scored 22 goals for club and country this season.
Rashford has featured in 13 matches – starting 11 of them – since the beginning of December, scoring nine goals in that period.